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, Volume 1756, Issue 1, pp 43–43 | Cite as


Acute invasive fungal rhinosinusitis (AIFR), systemic fungal infection and worsening of AIFR: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study, two women were described; A 20-year-old woman developed acute invasive fungal rhinosinusitis (AIFR) due to Talaromyces marneffei following treatment with antithymocyte globulin, ciclosporin, mycophenolate mofetil, methotrexate and unspecified chemotherapy for graft-versus-host disease (GVHD) prophylaxis and acute myeloid leukaemia (AML). A 21-year-old woman developed systemic fungal infection and AIFR due to Fusarium species following treatment with cytarabine and unspecified chemotherapy for AML. Additionally, she developed worsening of AIFR following treatment with antithymocyte globulin, busulfan, ciclosporin, mycophenolate mofetil and methotrexate for GVHD prophylaxis [dosages not stated; not all routes stated].

Case 1: The woman, who had...


  1. Cheng H-Y, et al. Surgical debridement for acute invasive fungal rhinosinusitis during the pre-engraftment phase of allogeneic hematopoietic stem cell transplantation: Two case reports. Medicine 97: No. 42, Oct 2018. Available from: URL: - China

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© Springer International Publishing AG 2019

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