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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 71-year-old woman developed acute inflammatory demyelinating polyneuropathy (AIPD) and chronic inflammatory demyelinating polyneuropathy (CIPD) following administration of morphine [inidication not stated].
The woman was scheduled to undergo a total hip arthroplasty. She received cefazolin [Ancef] and tranexamic acid followed by spinal epidural morphine [duramorph] 4.1 µg/kg and bupivacaine. There were no intra-operative complications. Following surgery, she underwent physical therapy and was discharged on warfarin. She was found to be coping well at the routine follow-up visits. However, 21 days after the surgery, she presented to the orthopaedic clinic with complaints of new-onset lower back pain, lower extremity weakness and imbalance. No other associated illness was...
- Hess SR, et al. Inflammatory demyelinating polyneuropathy after total hip arthroplasty. Arthroplasty Today 5: 17-20, No. 1, Mar 2019. Available from: URL: http://doi.org/10.1016/j.artd.2018.08.003 - USA