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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective multicenter cohort study of 52 women, 5 women [ages not stated] were described, who developed prosthetic heart valve thrombosis, postpartum haemorrhage or vaginal haematoma of the extremities and paracolpium following treatment with heparin, vitamin-K antagonists or low molecular weight heparins [specific drugs not stated] as anticoagulant therapy during pregnancy [dosages, outcomes and duration of treatments to reactions onsets not stated; not all routes stated]. Additionally, one of this woman received unspecified platelet activating factor inhibitors throughout pregnancy.
A woman, who was pregnant in 2010, underwent pulmonic valve replacement. She was treated with regimen 2 comprising low dose vitamin-K antagonists throughout pregnancy and IV heparin around...
- Lameijer H, et al. Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. International Journal of Cardiology 268: 106-112, Oct 2018. Available from: URL: http://doi.org/10.1016/j.ijcard.2018.05.038 - Netherlands