Reactions Weekly

, Volume 1747, Issue 1, pp 239–239 | Cite as


Cytomegalovirus infection, graft versus host disease and nephrotoxicity: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 5-year-old girl developed cytomegalovirus (CMV) infection and graft versus host disease (GVHD) during immunosuppressive therapy with prednisone and tacrolimus. Additionally, she developed nephrotoxicity during treatment with tacrolimus.

The girl, who had short gun syndrome, had undergone isolated intestinal transplantation. She was found to be CMV-seropositive. Post transplantation, she received immunosuppressive therapy with prednisone and tacrolimus [routes and initial dosages not stated] and a 14-day treatment with ganciclovir. Sixteen days after the transplantation, her cells continued to repopulate the allograft. At fourth week after the transplantation, ganciclovir was restarted due to increase in the CMV viral load. Five weeks after the transplantation, she developed...


  1. Stanley K, et al. Donor mucosal immunocytes perpetuate refractory GVHD after intestinal transplantation without engrafting in recipient bone marrow: Case report and review of the literature. Pediatric Transplantation 23: e13350, No. 2, Mar 2019. Available from: URL: - USA

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© Springer International Publishing AG 2019

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