Reactions Weekly

, Volume 1747, Issue 1, pp 145–145 | Cite as


GI disorders: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a case series, two men aged 45 years and 70 years were described, of whom the 45-year-old man developed duodenal ulcer, duodenal perforation and perforation peritonitis following treatment with ibuprofen and prednisolone for acute mountain sickness. Whereas, the 70-year-old man developed gastric perforation and perforation peritonitis following treatment with ibuprofen for pain management [routes and times to reactions onset not stated].

Case 1: The 45-year-old man, who had been trekking for seven days, developed nausea and vomiting at the height of 4900m. He received scopolamine butylbromide [buscopan], and he climbed further to a height of 5140m. At that point of time, he had further episodes of ongoing nausea, vomiting and severe abdominal cramps. Due to the concerns of...


  1. Amatya B, et al. Perforation peritonitis at high altitude. JNMA 56: 625-628, No. 210, Mar-Apr 2018. Available from: URL: - Nepal

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