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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, two men aged 45 years and 70 years were described, of whom the 45-year-old man developed duodenal ulcer, duodenal perforation and perforation peritonitis following treatment with ibuprofen and prednisolone for acute mountain sickness. Whereas, the 70-year-old man developed gastric perforation and perforation peritonitis following treatment with ibuprofen for pain management [routes and times to reactions onset not stated].
Case 1: The 45-year-old man, who had been trekking for seven days, developed nausea and vomiting at the height of 4900m. He received scopolamine butylbromide [buscopan], and he climbed further to a height of 5140m. At that point of time, he had further episodes of ongoing nausea, vomiting and severe abdominal cramps. Due to the concerns of...
- Amatya B, et al. Perforation peritonitis at high altitude. JNMA 56: 625-628, No. 210, Mar-Apr 2018. Available from: URL: http://doi.org/10.31729/jnma.3488 - Nepal