- 48 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series of 4 patients, three women aged 43−48 years were described, who developed Cytomegalovirus (CMV) infection reactivation following immunosuppressants and corticosteroid therapy with methylprednisolone, cyclophosphamide, azathioprine, prednisone, mycophenolate mofetil or rituximab for lupus nephritis [not all dosages, routes and times to reactions onsets stated].
Case 1 (the 48-year-old woman): The woman was diagnosed with systemic lupus erythematosus (SLE) at the age of 41 years. At the age of 46 years, she developed lupus nephritis ISN/RPS class 5, for which she received three IV infusions of methylprednisolone 500mg each, followed by IV infusion of cyclophosphamide. Subsequently, azathioprine 100 mg/day had been initiated as a maintenance therapy, along with...
- Sebastiani GD, et al. Cytomegalovirus infection in Systemic Lupus Erythematosus: report of four cases challenging the management of the disease, and literature review. Lupus 28: 432-437, No. 3, Mar 2019. Available from: URL: http://doi.org/10.1177/0961203319825570 - ItalyCrossRefPubMedGoogle Scholar