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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a study, a 72-year-old man developed severe interstitial lung damage secondary to drug-induced interstitial lung disease (DILD) and he eventually died due to radiation recall pneumonitis following treatment with carboplatin and pemetrexed for epitheliomorphic mesothelioma, a 63-year-old man died due to severe pulmonary fibrosis secondary to DILD following treatment with cisplatin and gemcitabine for lung adenocarcinoma, and a 72-year-old man died due to severe interstitial lung damage secondary to DILD following treatment with carboplatin, vinorelbine, nivolumab and docetaxel for squamous cell laryngeal carcinoma [routes and dosages not stated].
Case 1: A 72-year-old man was diagnosed with epitheliomorphic mesothelioma in May 2016 and underwent atypical resection of the upper...