Reactions Weekly

, Volume 1746, Issue 1, pp 134–134 | Cite as

Multiple drugs

Hypervitaminosis-D and associated complications: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 62-year-old woman experienced hypervitaminosis-D with associated hypercalcaemia, acute kidney injury (AKI) and renal calculi secondary to milk-alkali syndrome following iatrogenic use of calcium carbonate and calcitriol as calcium supplementation. The up-titration of losartan doses during the same time also contributed to the acute hypercalcaemia and AKI [not all routes and dosages stated; times to reactions onsets not clearly stated].

The woman had a solitary kidney and a history of end-stage renal disease secondary to diabetes and hypertension, managed with losartan and other unspecified medications. She presented to hospital 3 months following kidney transplantation with complaints of weakness, fatigue, altered mental staus and bilateral lower extremity pain. She...


  1. Kelly YP, et al. Iatrogenic Hypercalcemia Postrenal Transplantation. Kidney International Reports 4: 487-490, No. 3, Mar 2019. Available from: URL: - USA

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© Springer International Publishing AG 2019

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