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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
* Drug overdose
A 36-year-old woman developed cardiac arrhythmias following misuse and overdose of loperamide to manage diarrhoea due to self-diagnosed inflammatory bowel syndrome.
The woman was found minimally responsive on the floor with unknown downtime. She had last been seen normal 8 hours prior. She was hospitalised under the suspicion of a traumatic brain injury. Upon admission, she exhibited wide complex bradycardia with HR of 30 bpm, QTc of 831 msec, QRS of 170ms, a respiratory rate of 8 breaths per minute, undetectable BP, a temperature of 33.3°C and a blood glucose level of 50 mg/dL.
The woman was administered dextrose for hypoglycaemia. She also received atropine, following which her HR momentarily increased to 50s, and sodium bicarbonate to normalise the transient...
- Parker BM, et al. Loperamide induced cardiac arrhythmia successfully supported with veno-arterial ECMO (VA-ECMO), molecular adsorbent recirculating system (MARS) and continuous renal replacement therapy (CRRT). Clinical Toxicology : 26 Feb 2019. Available from: URL: http://doi.org/10.1080/15563650.2019.1580370 - USA