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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective, observational, cohort study of patients from adult status epilepticus registry between April 2006 to October 2017, 12 patients (7 women and 5 men) aged 20−90 years were described, who exhibited lack of efficacy during treatment of status epilepticus with carbamazepine, clobazam, clonazepam, ketamine, lacosamide, lamotrigine, levetiracetam, midazolam, oxcarbazepine, perampanel, phenytoin, pregabalin, propofol, thiopental-sodium, topiramate, valproic-acid or zonisamide [dosages and routes not stated].
Patient 1: The 25-year-old woman, who was diagnosed with N-methyl-D-aspartate receptor antibody (NMDA) encephalitis, developed an episode of status epilepticus (generalised convulsion) and received treatment with clonazepam, levetiracetam, carbamazepine and...
- Pantazou V, et al. Intravenous Corticosteroids as an Adjunctive Treatment for Refractory and Super-Refractory Status Epilepticus: An Observational Cohort Study. CNS Drugs 33: 187-192, No. 2, Feb 2019. Available from: URL: http://doi.org/10.1007/s40263-018-0600-y - SwitzerlandCrossRefPubMedGoogle Scholar