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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A case series described three patients [one man and two women; exact ages at reaction onset not stated], who developed ocular hypertension (OH) and asymmetric glaucoma (1 patient) or OH (2 patients) following treatment with aflibercept or ranibizumab as a anti-vascular endothelial growth factor (anti-VEGF) [dosages not stated].
Case 1: In September 2013, the woman was referred to a hospital for an opinion on filtering surgery at the age of 63 years. She had been treated with intravitreal ranibizumab injections for unilateral (right eye) exudative form of age-related macular degeneration (AMD). Between 2008 and 2013, a total of 20 intravitreal ranibizumab injections were administered (last injection in June 2013). Since 2011 (intravitreal injection No.13), a gradual onset of...
- Leleu I, et al. [Late and sustained intraocular pressure elevation related to intravitreal anti-VEGF injections: Cases requiring filtering surgery (French translation of the article)] Journal Francais d'Ophtalmologie 41: 789-801, No. 9, Nov 2018. Available from: URL: http://doi.org/10.1016/j.jfo.2018.03.014 [French; summarised from a translation] - FranceCrossRefPubMedGoogle Scholar