Reactions Weekly

, Volume 1739, Issue 1, pp 86–86 | Cite as


Infusion reaction and interstitial pneumonia: 6 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective study of 40 patients (administered cetuximab and radiotherapy from April 2013 through March 2016), six patients [including three 64−71 years old men; ages and sexes not stated for three patients] were described, who developed infusion reaction (three patients) and interstitial pneumonia (three patients) following treatment with cetuximab for locally advanced head and neck cancer [outcomes not stated; not all time to reactions onsets not stated].

Patient 1: The patient had locally advanced head and neck cancer. Prior to a radiation therapy, the patient was scheduled to receive cetuximab infusion 400 mg/m2 in the first week and then 250 mg/m2every week. The patient developed grade 2 infusion reaction from the initial dosage of cetuximab. The infusion reaction...


  1. Yamauchi M, et al. Acute toxicity and outcomes of radiotherapy plus cetuximab in locally advanced head and neck cancer. Japanese Journal of Head and Neck Cancer 44: 310-315, No. 3, Jan 2018. Available from: URL: [Chinese; summarised from a translation] - JapanGoogle Scholar

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