- 12 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a study, six patients [not all sexes stated] aged 38−67 years were described, who developed various toxicities, including allergic reactions, complaints in mouth, neutropenic fever, diarrhoea, nausea, leucopenia, hand-foot syndrome, abdominal cramps, thrombocytopenia, neutropenia, anorexia, fatigue, oral mucositis, stomatitis, fever or combinations thereof, during treatment with capecitabine for cancer [routes not stated].
Patient 1: A 50-year-old patient was initiated on capecitabine 1 000 mg/m2BID following various interventions for triple negative breast cancer (cT3N3M0). However, after cycle 1, the patient developed severe toxicity in the form of an allergic reaction, resulting in a swollen, red face, neutropenic fever, nausea, complaints in the mouth, diarrhoea and...
- Lunenburg CATC, et al. Diagnostic and therapeutic strategies for fluoropyrimidine treatment of patients carrying multiple DPYD variants. Genes 9: No. 12, 28 Nov 2018. Available from: URL: http://doi.org/10.3390/genes9120585 - Netherlands