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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 33-year-old woman developed disseminated cryptococcosis caused by Cryptococcus neoformans and eosinophilia during treatment with prednisolone for eosinophilic pneumonia [duration of treatment to reaction onsets not stated].
The woman was admitted at a clinic with an eight-day history of slight cough and fever. Subsequently, eosinophilic pneumonia was diagnosed, and she was started on prednisolone 30mg [route not stated] from admission day 2. After initiating prednisolone treatment, her wheezing resolved and fever improved; however, she developed headache from admission day 4, and her condition suddenly deteriorated. On admission day 8, lumbar puncture revealed a yeast-like fungus in the spinal fluid. She was diagnosed with Cryptococcus meningitis considering that the spinal...
- Nakamura K, et al. Disseminated Cryptococcosis with Eosinophilia and Elevated IgE in a Non-HIV-infected Patient. Kansenshogaku Zasshi 90: 819-24, No. 6, Nov 2016 [Japanese; summarised from a translation] - JapanGoogle Scholar