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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 24-year-old man developed antimicrobial resistance during treatment with avibactam/ceftazidime for Klebsiella pneumonia infection. He also developed renal tubular toxicity during treatment with polymixin-B, tigecycline and gentamicin.
The man, who had stage liver disease secondary to primary sclerosing cholangitis underwent orthotopic liver transplantation with Roux-en-Y hepaticojejunostomy. On day 4, he developed a fever and respiratory failure, which needed mechanical ventilator support. Blood and bronchoalveolar lavage fluid cultures grew Klebsiella pneumonia. A rapid nucleic acid microarray technology revealed presence of Klebsiella pneumoniae carbapenemase (KPC) encoding gene in the blood specimen. Consequently, an empirical regimen comprising of vancomycin and...
- Athans V, et al. Meropenem-vaborbactam as salvage therapy for ceftazidime-avibactam-resistant klebsiella pneumoniae bacteremia and abscess in a liver transplant recipient. Antimicrobial Agents and Chemotherapy 63: e01551-18, No. 1, Jan 2019. Available from: URL: http://doi.org/10.1128/AAC.01551-18 - USAPubMedGoogle Scholar