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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective study of four patients (hospitalised between April 2009 and January 2018), three patients (two women and one man) aged 38−63 years were described, who developed acute ischaemic stroke due to varicella zoster virus (VZV) vasculopathy during treatment with methotrexate, prednisolone, methylprednisolone, hydroxychloroquine or tacrolimus [durations of treatments to reactions onsets not stated not stated; not all dosages and routes stated].
Case 1: A 63-year-old woman was hospitalised with a sudden onset of right oculomotor nerve palsy (symptoms manifested as ophthalmoplegia, ptosis and pupil dilation with sluggish light reflex). She had been receiving oral prednisolone and methotrexate for rheumatoid arthritis. On the following day, she developed right facial...
- Hoshino T, et al. Ischemic Stroke due to Virologically-Confirmed Varicella Zoster Virus Vasculopathy: A Case Series. Journal of Stroke and Cerebrovascular Diseases 28: 338-343, No. 2, Feb 2019. Available from: URL: http://doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.001 - Japan