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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, a 75-year man developed autoimmune blistering disease with para-neoplastic pemphigus (PNP)-like features during treatment with pembrolizumab while a 64-year-old man developed Grover-like lesions and superimposed dermal hypersensitivity reaction during treatment with pembrolizumab.
Patient 1: The 75-year-old man, who had invasive, poorly differentiated squamous cell carcinoma of the tongue base with vascular invasion had received various medication without a satisfactory response. Therefore, he started receiving pembrolizumab 2 mg/kg. His medical history included psoriasis, managed with triamcinolone and calcipotriol, hypothyroidism treated with levothyroxine sodium, and hypertension controlled with metoprolol and amlodipine. At approximately 82 days after...
- Chen WS, et al. Suprabasal acantholytic dermatologic toxicities associated checkpoint inhibitor therapy: A spectrum of immune reactions from paraneoplastic pemphigus-like to Grover-like lesions. Journal of Cutaneous Pathology 45: 764-773, No. 10, Oct 2018. Available from: URL: http://doi.org/10.1111/cup.13312 - USA