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An event is serious (based on the ICH definition) when the patient outcome is:Drug overdose
* congenital anomaly
* other medically important event
A 38-year-old woman developed altered mental status, pulseless electrical activity, cardiogenic shock, vasogenic shock, respiratory failure and asystole due to polypharmacy-overdose including amlodipine, amitriptyline, clonazepam, cyproheptadine, promethazine and montelukast, and exhibited lack of efficacy to treatment with epinephrine, sodium bicarbonate, calcium gluconate, naloxone, norepinephrine, atropine, insulin, lipid emulsion and glucagon [dosages not stated; not all routes stated].
The woman was brought to the emergency department (ED) with poly-substance overdose after her husband found her with several empty pill bottles nearby. The ingestion was estimated to have occurred 3−12 hours before arrival to the ED. Her mental status was altered, so she...
- Chung J, et al. Venoarterial extracorporeal membrane oxygenation for polypharmacy-induced cardiogenic shock and respiratory failure. American Surgeon 84: E483-E484, No. 11, Nov 2018. Available from: URL: https://www.ingentaconnect.com/content/sesc/tas/2018/00000084/00000011/art00016 - USA