- 21 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective review, six patients [five women and one man] aged 68−81 years were described, who developed cardiotoxicity manifesting as florid pulmonary oedema, ST-elevation myocardial infarction, cardiac arrest or atrial fibrillation with a rapid ventricular rate during treatment with trabectedin, doxorubicin, doxorubicin liposomal or unspecified anthracycline [not all routes, dosages and outcomes stated].
Case 1: A 71-year-old woman developed cardiotoxicity manifesting as florid pulmonary oedema during treatment with doxorubicin and trabectedin for uterine leiomyosarcoma. The woman was initially diagnosed with a grade 3 FIGO stage 1C uterine leiomyosarcoma, which was surgically resected. Eight years later, disease recurrence was observed in the pancreas, right...