Reactions Weekly

, Volume 1736, Issue 1, pp 81–81 | Cite as


Development of antimicrobial resistance in staphylococcal infection and neutropenia: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 60-year-old woman and a 71-year-old man developed antimicrobial resistance during treatment with daptomycin for Staphylococcal infection. The woman also developed neutropenia during treatment with vancomycin as empiric treatment.

Case 1: The 60-year-old woman had a history of hypertrophic cardiomyopathy. Two years before, she had undergone implantation of a left ventricular assist device. After 18 months, she underwent an emergent exchange surgery due to sudden malfunctioning of the device. Subsequently, she developed a surgical site infection, which was treated with ampicillin/sulbactam. After 3 months, she was re-hospitalised with a low-grade fever and tenderness directly around the pump, arose due to recurrence of the surgical wound infection. She was found to have...


  1. Hagiya H, et al. Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis. Medicine 97: e13487, No. 49, Dec 2018. Available from: URL: - Japan

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