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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 60-year-old woman and a 71-year-old man developed antimicrobial resistance during treatment with daptomycin for Staphylococcal infection. The woman also developed neutropenia during treatment with vancomycin as empiric treatment.
Case 1: The 60-year-old woman had a history of hypertrophic cardiomyopathy. Two years before, she had undergone implantation of a left ventricular assist device. After 18 months, she underwent an emergent exchange surgery due to sudden malfunctioning of the device. Subsequently, she developed a surgical site infection, which was treated with ampicillin/sulbactam. After 3 months, she was re-hospitalised with a low-grade fever and tenderness directly around the pump, arose due to recurrence of the surgical wound infection. She was found to have...
- Hagiya H, et al. Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis. Medicine 97: e13487, No. 49, Dec 2018. Available from: URL: http://doi.org/10.1097/MD.0000000000013487 - Japan