- 30 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, a 63-year-old man developed B-cell small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL) during treatment with methotrexate for psoriatic arthritis, and a 54-year-old man developed T-cell lymphoma during treatment with azathioprine, methotrexate and prednisone for dermatomyositis.
Case 1: The 63-year-old man, who had a history of psoriatic arthritis and hypertension, presented with
fevers and night sweats. He was diagnosed with psoriatic arthritis in the mid-1990s and had been well controlled on methotrexate 15mg weekly [route not stated] since the mid-1990s. He had also been receiving treatment with losartan for hypertension and folic acid supplements. He was a former smoker and quit smoking in 1993. He drank alcohol socially and denied use...
- Ross Y, et al. Treatment of advanced stage methotrexate-associated lymphoproliferative disorders (MTX-LPDs) with methotrexate discontinuation. BMJ Case Reports 11: e226545, No. 1, Dec 2018. Available from: URL: http://doi.org/10.1136/bcr-2018-226545 - USA