- 25 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, a 35-year-old woman and 30-year-old woman developed differentiation syndrome (DS) with ocular manifestations during treatment with tretinoin and arsenic trioxide for acute promyelocytic leukaemia (APL) [routes not stated; not all durations of treatments to reaction onsets stated].
Case 1: A 35-year-old woman was diagnosed with APL in July 2016 and started on APML4 chemotherapy protocol with tretinoin [all-trans retinoic acid; ATRA] 45 mg/m2and idarubicin on days 2, 4, 6 and 8 and arsenic trioxide 0.15 mg/kg from day 9 onwards of the protocol. She was taking prednisolone from day 1−10 as a prophylactic therapy for DS. On day 11 of the therapy, she developed a mild headache and became febrile and hypotensive. She was started on vancomycin and...
- Newman AR, et al. Two cases of differentiation syndrome with ocular manifestations in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide. American Journal of Ophthalmology Case Reports 9: 106-111, Mar 2018. Available from: URL: http://doi.org/10.1016/j.ajoc.2018.01.026 - AustraliaCrossRefPubMedPubMedCentralGoogle Scholar