Reactions Weekly

, Volume 1736, Issue 1, pp 43–43 | Cite as

Antineoplastics/opioid analgesics

Various toxicities: case report
Case report

A 62-year-old patient [sex not stated] developed peripheral polyneuropathy and neutropenia during treatment with FOLFIRNOX regimen comprising fluorouracil, folinic acid, irinotecan and oxaliplatin for inoperable pancreatic cancer. Additionally, the patient developed constipation, nausea and vomiting during treatment with morphine, fentanyl and oxycodone for treatment of pain related to pancreatic cancer [durations of treatments to reactions onsets not stated].

The patient, who had inoperable pancreatic cancer, started receiving 12 courses of the FOLFIRNOX regimen comprising fluorouracil, folinic acid [calcium folinate], irinotecan and oxaliplatin [dosages and routes not stated]. During the subsequent courses of the chemotherapy, the patient developed grade I neutropenia. The neoplastic lesion was located in the head of the pancreas. The patient reported epigastric pain radiating to the spine at Th10−12. The patient also felt numbness and tingling in the hands and feet. The numbness...


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