- 6 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, three patients (1 woman and 2 men) aged 51−75 years were described, of whom a 75 year-old man developed hypophysitis, adrenal insufficiency and hypogonadotrophic hypogonadism, a 68-year-old woman developed hypophysitis, panhypopituitarism, adrenal insufficiency and hypothyroidism, and a 51-year-old man developed hypophysitis, panhypopituitarism, adrenal insufficiency, hypogonadotrophic hypogonadism and hypothyroidism, during treatment with ipilimumab for metastatic melanoma [dosages, routes and durations of treatments to reactions onsets not stated; not all outcomes stated].
Case 1: The 75-year-old man, who had right ear melanoma metastatic to posterior cervical lymph nodes and lung, had received two cycles of ipilimumab therapy two years apart. Each...
- Wadhwa V. Ipilimumab Induced Hypophysitis: MRI Findings in a Series of 3 Cases. Journal of the Arkansas Medical Society 113: 270-272, No. 11, May 2017 - USAGoogle Scholar