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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, three men aged 54−71 years were described, who developed hypertriglyceridaemia during treatment with capecitabine [routes not stated] for metastatic colorectal cancer (mCRC) or metastatic rectal adenocarcinoma.
Case 1: A 54-year-old man, who had recurrent metastatic rectal adenocarcinoma to the bilateral lungs, received treatment with capecitabine 850 mg/m2twice daily for 14 days every 21 days, oxaliplatin and bevacizumab (XELOX-bevacizumab regimen). He had previously received neoadjuvant chemoradiation with capecitabine, and adjuvant capecitabine and oxaliplatin for locally advanced disease. Prior to the completion of cycle 6 of current therapy, his triglyceride levels were found to be at 3783 mg/dL. The chemotherapy was interrupted due to asymptomatic...