Reactions Weekly

, Volume 1735, Issue 1, pp 64–65 | Cite as

Buprenorphine/naloxone abuse

Ischaemic hand Complications: 10 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A retrospective study that included review of patient records between 2011 and 2015, described 10 adult patients, including a 24-year-old woman [not all ages and sexes stated], who developed ischaemias of the ring finger (1 patient), thumb (4 patients), thumb and long finger (1 patient), index and long finger (1 patient), index, long and ring finger (1 patient) or thumb and index finger (2 patients), leading to varying levels of tissue loss in all the patients and also dry gangrene in one of these patients, following intra-arterial administration of sublingual form of buprenorphine/naloxone (abuse) [dosages not stated; not all times to reactions onsets and outcomes stated].

Patient 1: An opioid dependant adult patient received intra-arterial injection of sublingual form of...


  1. Wilson RM, et al. Ischemic Hand Complications From Intra-Arterial Injection of Sublingual Buprenorphine/Naloxone Among Patients With Opioid Dependency. Hand 12: 507-511, No. 5, 1 Sep 2017. Available from: URL: - USACrossRefPubMedGoogle Scholar

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