Reactions Weekly

, Volume 1735, Issue 1, pp 35–35 | Cite as


Drug-hypersensitivity and anaphylaxis: 4 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study of 886 children conducted between January 2011 and July 2016, 4 children1 (2 boys and 2 girls) age ranged 6−12.9 years were described who developed drug hypersensitivity (three children) and anaphylaxis (one child) following treatment with amoxicillin/clavulanic-acid [amoxicillin/clavulanate], ciprofloxacin, clarithromycin or paracetamol [routes, dosages, indications, duration of treatments to reaction onsets and final outcomes not stated].

Patient 1: The 6-year-old girl developed drug hypersensitivity following treatment with amoxicillin/clavulanic-acid and clarithromycin. The girl had family history of penicillin allergy. At the age of 6 years, while receiving treatment with amoxicillin/clavulanic-acid, she developed urticaria. Similarly, at the age of 8 years,...


  1. Guvenir H, et al. Proven immunologically-mediated drug hypersensitivity in children with a history of multiple drug intolerances. Annals of Allergy, Asthma and Immunology 122: 73-78.e1, No. 1, Jan 2019. Available from: URL: - TurkeyCrossRefPubMedGoogle Scholar

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