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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 69-year-old man developed meningoencephalitis, respiratory failure and aspiration pneumonia secondary to disseminated herpes zoster (DHZ) following immunosuppression therapy with methylprednisolone and prednisolone. His DHZ was refractory to aciclovir and eventually he died due to respiratory failure secondary to aspiration pneumonia, despite treatment with aciclovir for disseminated DHZ.
The man, who had been receiving treatment with amiodarone for paroxysmal atrial fibrillation, was hospitalised in August 2016 with a diagnosis of amiodarone-induced interstitial pneumonia. His treatment with amiodarone was then discontinued and he started receiving treatment with IV methylprednisolone 1000mg daily for 3 days, followed by oral prednisolone 60mg daily. His past medical history...
- Fujisato S, et al. A Fatal Case of Atypical Disseminated Herpes Zoster in a Patient with Meningoencephalitis and Seizures Associated with Steroid Immunosuppression. American Journal of Case Reports 19: 1162-1167, Oct 2018. Available from: URL: http://doi.org/10.12659/AJCR.910521 - JapanCrossRefPubMedGoogle Scholar