Reactions Weekly

, Volume 1734, Issue 1, pp 346–346 | Cite as

Multiple drugs

Spontaneous abortion, preterm delivery and congenital cryptorchidism: 8 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective analysis of patient records from January 2007 to December 2012, seven pregnant women aged 31−45 years were described, who were inadvertently exposed to category X drugs (drugs contraindicated in pregnancy) including medroxyprogesterone, estradiol valerate/norgestrel, ethinylestradiol/desogestrel, caffeine/ergotamine/mecloxamine/paracetamol, atorvastatin or estradiol benzoate/progesterone during first trimester of pregnancy, which resulted in spontaneous abortion (five women) and preterm delivery (two women). Additionally, a male neonate was also described, who was born with congenital cryptorchidism following in-utero exposure to estradiol valerate/norethisterone during first trimester [not all duration of treatments to reactions onsets stated].

Case 1: A...


  1. Ozturk Z, et al. Birth outcomes after inadvertent use of category x drugs contraindicated in pregnancy: Where is the real risk?. Turkish Journal of Pediatrics 60: 298-305, No. 3, Jan 2018. Available from: URL: - Turkey

Copyright information

© Springer Nature Switzerland AG 2019

Personalised recommendations