Desflurane/rocuronium bromide/suxamethonium chloride
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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 52-year-old man developed malignant hyperthermia following the administration of desflurane, rocuronium bromide [rocuronium] and suxamethonium chloride [succinylcholine].
The man presented to a hospital with a minimally displaced right parasymphyseal fracture and moderately displaced left body fracture of the mandible. The open reduction-internal fixation of bilateral mandibular fractures was planned two days after admission. At 3:52PM, he arrived in the operating room and received induction IV rocuronium bromide 5mg as a muscle relaxant and IV suxamethonium chloride 120mg [therapeutic indication not stated] along with various other medications including unspecified antibiotics. At around 4:00PM, he started receiving desflurane gas (flow rate 6%) for maintenance of general...
- Gibbs IC, et al. Malignant Hyperthermia: A Case Report in a Trauma Patient. Journal of Oral and Maxillofacial Surgery 77: 54-58, No. 1, 19 Jul 2019. Available from: URL: http://doi.org/10.1016/j.joms.2018.07.009 - USA