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, Volume 1733, Issue 1, pp 223–223 | Cite as

Methotrexate

Pancytopenia, and death due to sepsis: 10 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective analysis of data of patients who met the ACR 2010 criteria of diagnosis, cases of 10 patients aged 64−75 years [sexes not stated] were described, who developed pancytopenia during toxicity with low-dose (<25−35 mg/week) methotrexate for rheumatoid arthritis; out of them 3 patients took incorrect dose of methotrexate and 1 patient died of sepsis.

Case 1: An 81-year-old patient, who had a 15-year-long medical history of rheumatoid arthritis, presented with fever, oral ulcer, mucositis and weakness. Concurrent conditions included deep vein thrombosis and pulmonary thromboembolism. The patient had a disease activity score (DAS-28) of 1.49 for rheumatoid arthritis. The patient was prescribed methotrexate 10 mg/week [route not stated] for rheumatoid arthritis. The...

Reference

  1. Cansu DU, et al. How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis?. Clinical Rheumatology 37: 3419-3425, No. 12, Dec 2018. Available from: URL: http://doi.org/10.1007/s10067-018-4242-8 - Turkey

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© Springer Nature Switzerland AG 2018

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