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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A systemic review study described 7 patients1 (4 women and 3 men) aged 32−56 years, who developed anaphylaxis to cefazolin (between January 2012 and December 2016) following prophylactic perioperative administration of cefazolin. One of these patient additionally developed Kounis syndrome [dosages and times to reactions onsets not stated; not all outcomes stated].
The 32-year-old woman received prophylactic IV cefazolin during her labour. However, she immediately developed anaphylaxis to cefazolin, which was manifested as facial angioedema and dyspnoea. Thereafter, she underwent an intradermal skin test with cefazolin 0.25 mg/mL, which resulted in cough, oral pruritus and facial angioedema (positive for cefazolin).
The 40-year-old woman, who had underlying chronic urticaria,...