Reactions Weekly

, Volume 1731, Issue 1, pp 62–62 | Cite as


Various toxicities: 6 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a prospective, non-randomised study conducted between May 2011 to November 2015, 6 women were described, who developed various toxicities during treatment with bevacizumab, carboplatin or paclitaxel for epithelial ovarian cancer (EOC) [not all routes, dosages, time to reactions onset and outcomes stated].

Patient 1: The woman developed hypertension during treatment with carboplatin and paclitaxel. The woman had a diagnosis of EOC, for which she initially underwent maximal surgical debulking. Thereafter, she started receiving paclitaxel 175 mg/m2 and carboplatin (AUC 6) on day 1 every 3 weeks. During the chemotherapy, she developed grade 2 hypertension. Despite this, she completed the scheduled 6 cycles of the chemotherapy.

Patient 2: The woman developed hypertension during...


  1. Vatsa R, et al. Frontline use of Bevacizumab in ovarian cancer: Experience from India. National Medical Journal of India 31: 15-18, No. 1, Jan-Feb 2018. Available from: URL: - India

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