Reactions Weekly

, Volume 1731, Issue 1, pp 39–39 | Cite as


Leukoencephalopathy: 4 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective review of nine patients diagnosed with leukaemia or lymphoma, four patients (two girls and two boys) aged 10−13 years were described, who experienced methotrexate-induced stroke like neurotoxicity in the form of leukoencephalopathy, which was further potentiated by cyclophosphamide, cytarabine, mercaptopurine and prednisolone [not all routes stated; dosages not stated].

Patient 1: An 11-year-old boy diagnosed with B-cell precursor acute lymphoblastic leukaemia started receiving chemotherapy comprising intrathecal methotrexate in the induction phase, two doses of cyclophosphamide over 4 weeks, four blocks of cytarabine, oral mercaptopurine [6-mercaptopurine], prednisolone and two doses of intrathecal methotrexate during the early intensification phase. However,...


  1. Watanabe K, et al. Characteristics of methotrexate-induced stroke-like neurotoxicity. International Journal of Hematology 108: 630-636, No. 6, Dec 2018. Available from: URL: - JapanCrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations