Reactions Weekly

, Volume 1731, Issue 1, pp 20–20 | Cite as


Worsening of oropharyngeal bleeding and intracranial haemorrhage: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A male neonate [age at the time of reaction onset not clearly stated] developed worsening of oropharyngeal bleeding and intracranial haemorrhage during treatment with alteplase [Activase] for systemic thrombolysis of an occlusive aortic thrombus. Subsequently, he died.

The 5-day-old male neonate, who was born at 38th weeks of gestational age, presented for extracorporeal membrane oxygenation [ECMO) to treat his respiratory failure. His treatment at the birth hospital, was started with the initiation of positive pressure ventilation for tachypnoea a few hours after birth and then intubation and mechanical ventilation were performed. He was diagnosed with persistent pulmonary hypertension. Immediately before transfer, he developed pulmonary haemorrhage, which required exchange of...


  1. Onwubiko C, et al. Systemic thrombolysis of an occlusive aortic thrombus in a neonate on extracorporeal membrane oxygenation. American Surgeon 84: E372-E374, No. 9, 01 Sep 2018. Available from: URL: - USA

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations