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, Volume 1730, Issue 1, pp 165–165 | Cite as


Pneumocystis jirovecii pneumonia: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

  • * Drug interaction

A 66-year-old woman developed Pneumocystis jirovecii pneumonia (PCP) during treatment with etanercept, iguratimod, prednisolone and methotrexate for rheumatoid arthritis (RA). The co-administration of methotrexate and iguratimod could have lead to increased immunosuppression.

The woman, who had a history of rheumatoid arthritis for 13 years, was transferred to a hospital in November 2015, due to dry cough, fever and dyspnoea at rest for 1 week. Since 8 years, she had been receiving methotrexate 4 mg/week and prednisolone 2 mg/day, along with SC etanercept 50 mg/week since 4 years. However, in August 2015, the medications showed limited efficacy, owning to the addition of iguratimod 25 mg/day [not all the routes stated]. Her laboratory findings at presentation...


  1. Arita Y, et al. Pneumocystis jirovecii pneumonia developed in a patient with rheumatoid arthritis after 14 weeks of iguratimod add-on to treatment with methotrexate and etanercept. Modern rheumatology / the Japan Rheumatism Association 28: 1041-1043, No. 6, May 2018. Available from: URL: - Japan

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