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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 38-year-old woman developed disseminated extrapulmonary Legionella pneumophila infection, cytomegalovirus (CMV) infection, varicella zoster virus infection and lymphopenia following treatment with prednisolone, hydroxychloroquine and azathioprine for systemic lupus erythematosus (SLE) [routes not stated].
The woman, who had SLE, started receiving treatment with prednisolone and azathioprine [initial dose not stated]. She continued receiving treatment with prednisolone 5 mg/day and azathioprine 50 mg/day for the next 13 years. In August 2015, she developed cramping abdominal pain, watery diarrhoea two or three times daily and low-grade fever. Subsequently, she was diagnosed with enteritis.
The woman was treated with ceftriaxone. The dose of her immunosuppressive medication was...
- Chitasombat MN, et al. Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: Case report and literature review. BMC Infectious Diseases 18: 467, No. 1, 17 Sep 2018. Available from: URL: http://doi.org/10.1186/s12879-018-3378-0 - ThailandCrossRefPubMedPubMedCentralGoogle Scholar