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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A case series described two boys and one girl [not all ages at the time of reaction onset stated] who developed amiodarone induced type 2 thyrotoxicosis (AIT). One 17.3-year-old boy was additionally treated with prednisone, which further contributed to the development of amiodarone induced thyrotoxicosis.
Case 1: A boy, who had a history of sick sinus syndrome, pacemaker implantation and a corrective surgery for aortic valve stenosis, presented with a new episode of atrial flutter at the age of 17.3 years. He started receiving IV amiodarone 150mg [frequency not stated] and underwent electric cardioversion. This was followed by maintenance therapy with oral amiodarone, which involved a loading dose of 200mg twice daily for three days, and later 200mg once daily for six days a...
- Gesing J, et al. Diagnosis and Clinical Course of Three Adolescents with Amiodarone-Induced Hyperthyroidism. Pediatric Cardiology 39: No. 7, Oct 2018. Available from: URL: http://doi.org/10.1007/s00246-018-1981-x -Germany