Reactions Weekly

, Volume 1722, Issue 1, pp 225–225 | Cite as


Various toxicities: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 57-year-old woman developed low level BK polyomavirus (BKPyV) infection associated with high-grade metastatic sarcomatoid urothelial carcinoma with urothelial carcinoma in situ during treatment with methylprednisolone, mycophenolate-mofetil and tacrolimus used as an immunosuppressants [routes not stated; duration of treatments to reactions onset not stated].

The woman, who had a chronic kidney failure, underwent a kidney transplant from a deceased donor. Thereafter, she started receiving immunosuppressive treatment with methylprednisolone 4mg daily, mycophenolate mofetil 500mg twice a day and tacrolimus 5mg twice a day. The immunosuppressants dosages were dynamically adjusted to maintain target serum concentrations. Notably, she had a long-term BKPyV infection. The BKPyV...


  1. Fu F, et al. Occurrence and regression of BK polyomavirus associated carcinoma: A clinical and next-generation sequencing study. Clinical Science 132: 1753-1763, No. 16, 30 Aug 2018. Available from: URL: - China

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations