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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, an 81-year-old man and a 77-year-old man were described, who developed severe thrombocytopenia following re-exposure to piperacillin/tazobactam treatment [route and dosage not stated].
Case 1: An 81-year-old man developed severe thrombocytopenia following re-exposure to piperacillin/tazobactam treatment for lower lobe pneumonia. The man had type II diabetes, depression, dementia, chronic obstructive pulmonary disease and hypertension. His chest X-ray revealed left lower lobe pneumonia, and he started therapy with moxifloxacin and piperacillin/tazobactam. Unfortunately, he became hypoxic and his condition deteriorated. He was then transferred to another hospital with a diagnosis of hypoxic respiratory failure. After hospitalisation, he continued on vasopressors...
- Alzahrani M, et al. Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature. Platelets 29: 628-631, No. 6, 18 Aug 2018. Available from: URL: http://doi.org/10.1080/09537104.2018.1468025 - Saudi Arabia