Reactions Weekly

, Volume 1719, Issue 1, pp 160–160 | Cite as

Multiple drugs

Various toxicities: 5 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study consisting of 10 patients, five patients (three men and two women) aged 21-52 years were described, who developed cytomegalovirus (CMV) reactivation, Escherichia coli urinary tract infection (UTI), oral HSV1 infection, coronavirus influenza, graft-versus-host disease (GVHD) or Enterococcus UTI following treatment with alemtuzumab, antithymocyte globulin [rabbit antithymocyte globulin], cyclophosphamide, fludarabine, mycophenolate mofetil or sirolimus as conditioning regimen for haploidentical haematopoietic stem cell transplantation (HSCT) or GVHD prophylaxis [routes, duration of treatments to reaction onsets and outcomes not stated for all].

Patient B from table 1 of the article: A 52-year-old man developed CMV reactivation following treatment with alemtuzumab and...


  1. Saraf SL, et al. Haploidentical Peripheral Blood Stem Cell Transplantation Demonstrates Stable Engraftment in Adults with Sickle Cell Disease. Biology of Blood and Marrow Transplantation 24: 1759-1765, No. 8, Aug 2018. Available from: URL: - USACrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations