Reactions Weekly

, Volume 1719, Issue 1, pp 135–135 | Cite as


Various toxicities: 11 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective case series of 1871 patients conducted between 1980 and 2015, 11 patients (7 women and 4 men) aged 44−681 years were described, of whom 7 patients developed thyroid papillary carcinoma alone, 3 patients developed renal cancer and 1 patient developed both thyroid papillary carcinoma and renal cancer during treatment with lithium [routes and durations of treatments to reactions onsets not stated; not all dosages, indications and outcomes stated]. Of these 11 patients, one patient died due to renal cancer, another died due to respiratory failure secondary to pulmonary metastases and the third patient died due to cerebral metastases of non-small cell lung cancer.

Case 1: A 60-year-old woman, who was on long term lithium therapy, developed thyroid papillary...


  1. Ambrosiani L, et al. Thyroid and renal tumors in patients treated with long-term lithium: case series from a lithium clinic, review of the literature and international pharmacovigilance reports. International Journal of Bipolar Disorders 6: 17, No. 1, 6 Aug 2018. Available from: URL: - ItalyCrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations