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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 46-year-old woman developed ovarian small cell carcinoma of pulmonary type during treatment with tamoxifen.
The woman, who had a history of left breast cancer, had undergone mastectomy and sentinel lymph node biopsy in 2013. The post-operative pathology showed an invasive ductal carcinoma of the left breast. She had been receiving treatment with oral tamoxifen 20mg daily for 2 years. In August 2015, she experienced abdominal distension, anorexia, dyschezia and weight loss of 6 months duration. A chest CT scan revealed multiple enlarged lymph nodes of mediastinal para-aortic arch. Abdominal and pelvic CT scanning identified a huge pelvic tumour and ascites. The tumour was approximately 15.8 × 10cm in size, and revealed a mixed pattern of multi-cystic and solid parts. Tumour...
- Yin L, et al. Primary ovarian small cell carcinoma of pulmonary type with coexisting endometrial carcinoma in a breast cancer patient receiving tamoxifen: A case report and literature review. [Review]. Medicine 97: e10900, No. 23, Jun 2018. Available from: URL: http://doi.org/10.1097/MD.0000000000010900 - China