Triclofos Sodium for Pediatric Sedation in Non-Painful Neurodiagnostic Studies

  • Eytan KaplanEmail author
  • Ayman Daka
  • Avichai Weissbach
  • Dror Kraus
  • Gili Kadmon
  • Rachel Milkh
  • Elhanan Nahum
Original Research Article



Triclofos sodium (TFS) has been used for many years in children as a sedative for painless medical procedures. It is physiologically and pharmacologically similar to chloral hydrate, which has been censured for use in children with neurocognitive disorders. The aim of this study was to investigate the safety and efficacy of TFS sedation in a pediatric population with a high rate of neurocognitive disability.


The database of the neurodiagnostic institute of a tertiary academic pediatric medical center was retrospectively reviewed for all children who underwent sedation with TFS in 2014. Data were collected on demographics, comorbidities, neurologic symptoms, sedation-related variables, and outcome.


The study population consisted of 869 children (58.2% male) of median age 25 months (range 5–200 months); 364 (41.2%) had neurocognitive diagnoses, mainly seizures/epilepsy, hypotonia, or developmental delay. TFS was used for routine electroencephalography in 486 (53.8%) patients and audiometry in 401 (46.2%). Mean (± SD) dose of TFS was 50.2 ± 4.9 mg/kg. Median time to sedation was 45 min (range 5–245), and median duration of sedation was 35 min (range 5–190). Adequate sedation depth was achieved in 769 cases (88.5%). Rates of sedation-related adverse events were low: apnea, 0; desaturation ≤ 90%, 0.2% (two patients); and emesis, 0.35% (three patients). None of the children had hemodynamic instability or signs of poor perfusion. There was no association between desaturations and the presence of hypotonia or developmental delay.


TFS, when administered in a controlled and monitored environment, may be safe for use in children, including those with underlying neurocognitive disorders.



We thank Mrs Pnina Lilos for her insights regarding the study design and assistance in the data analysis and interpretation.

Compliance with Ethical Standards

Conflict of interest

All authors including EK, AD, AW, DK, GK, RM, and EN have no conflicts of interest to disclose.

Funding source

No funding was secured for this study.

Ethical approval and informed consent

The study was approved by the Institutional Review Board of Schneider Children’s Medical Center of Israel with a waiver of parental consent owing to the retrospective study design (RMC-0010-15).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Pediatric Intensive Care UnitSchneider Children’s Medical Center of IsraelPetach TikvaIsrael
  2. 2.Pediatric Sedation ServicesSchneider Children’s Medical Center of IsraelPetach TikvaIsrael
  3. 3.Institute of NeurologySchneider Children’s Medical Center of IsraelPetach TikvaIsrael
  4. 4.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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