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Pediatric Drugs

, Volume 21, Issue 2, pp 71–79 | Cite as

Medical Options for the Adjuvant Treatment and Management of Pediatric Melanoma

  • Haya S. Raef
  • Alison M. Friedmann
  • Elena B. HawrylukEmail author
Review Article

Abstract

Although melanoma is a rare diagnosis in the pediatric population, advances in the management of adults with melanoma offer the prospect of promising therapeutic options for children. At this time, medical management is not considered curative but may reduce the risk of recurrence or prolong survival. Surgical management remains the mainstay of treatment. Medical therapy of pediatric melanoma is not thought to have a role for in situ, early-stage, or localized disease, but adjuvant therapy may have a role in improving the prognosis of patients with positive sentinel lymph node biopsy (SLNB), spread beyond the regional lymph node basin, metastatic disease, or recurrent disease. Medical treatment options include immunotherapies, particularly checkpoint inhibitors, and targeted therapies, which have provided improved toxicity profiles compared with traditional chemotherapy regimens in the setting of advanced disease. There is a growing body of pediatric-specific data relevant to the use of adjuvant therapies for advanced melanoma in children.

Notes

Compliance with Ethical Standards

Funding

This work was funded by the Dermatology Foundation and the Society for Pediatric Dermatology (EBH).

Conflicts of Interest

Elena B. Hawryluk’s spouse has received stock from Foundation Medicine Inc. and salary and stock from Gritstone Oncology. Elena B. Hawryluk has received authorship honorarium from UpToDate, Inc. Haya S. Raef and Alison M. Friedmann, MD, MSc, have no conflicts of interest that might be relevant to the contents of this manuscript.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Tufts University School of MedicineBostonUSA
  2. 2.School of MedicineHarvard UniversityBostonUSA
  3. 3.Department of PediatricsMassachusetts General HospitalBostonUSA
  4. 4.Department of DermatologyMassachusetts General HospitalBostonUSA
  5. 5.Dermatology Program, Division of Immunology, Department of MedicineBoston Children’s HospitalBostonUSA

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