Drugs & Therapy Perspectives

, Volume 35, Issue 12, pp 619–620 | Cite as

Vitamin D with calcium supplements: a new hope for the treatment of dengue infection

  • Muhammad Torequl IslamEmail author
Letter to the Editor

Dengue, a mosquito-borne viral infection, is one of the major public health problems in tropical and sub-tropical areas worldwide. Dengue virus (DENV) is transmitted by the female mosquito, Aedes spp., mainly by Ae. aegypti and Ae. albopictus [1]. However, Ae. polynesiensis and Ae. niveus have been reported as two more secondary vectors in some regions of the world [2]. Recently, it has been seen that a deficiency of vitamins B12 and D may cause pyrexia of unknown origin, hemolytic anemia, and thrombocytopenia in humans [3]. A correlation has been seen between the wild-type AA MBL2 genotype and age as associated risk factors for development of DENV-related thrombocytopenia [4]. Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of DENV and the mechanisms that regulate production of cytokines (e.g., tumor necrosis factor-α, and interleukin-1β, -6, -12p70, -10, and -4) [5, 6, 7, 8].

It has been...


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No sources of funding were declared.

Conflict of interest

The author declares that he has  no competing interests.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pharmacy, Life Science FacultyBangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganjBangladesh

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