Vitamin D with calcium supplements: a new hope for the treatment of dengue infection
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Dengue, a mosquito-borne viral infection, is one of the major public health problems in tropical and sub-tropical areas worldwide. Dengue virus (DENV) is transmitted by the female mosquito, Aedes spp., mainly by Ae. aegypti and Ae. albopictus . However, Ae. polynesiensis and Ae. niveus have been reported as two more secondary vectors in some regions of the world . Recently, it has been seen that a deficiency of vitamins B12 and D may cause pyrexia of unknown origin, hemolytic anemia, and thrombocytopenia in humans . A correlation has been seen between the wild-type AA MBL2 genotype and age as associated risk factors for development of DENV-related thrombocytopenia . Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of DENV and the mechanisms that regulate production of cytokines (e.g., tumor necrosis factor-α, and interleukin-1β, -6, -12p70, -10, and -4) [5, 6, 7, 8].
It has been...
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The author declares that he has no competing interests.
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