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Sensitivity pattern of cefotaxime against common uropathogens in vitro in Dhaka, Bangladesh

  • Md. Jahangir AlamEmail author
  • Runa Asma
  • Sumi Shohela Chowdury
  • Md. Rahimgir
Original Research Article
  • 4 Downloads

Abstract

Background

The most common nosocomial infection worldwide is urinary tract infection (UTI), which can be treated with various antimicrobial agents.

Objective

The aim of this study was to assess the efficacy of cefotaxime, a third-generation cephalosporin, against potential uropathogens.

Methods

This study was carried out by retrospective analysis of laboratory data routinely collected from the Microbiology Department of the Ibn Sina Diagnostic and Consultation Center, Dhaka, Bangladesh. We used conventional methods for urine culture and sensitivity, the disc diffusion method for susceptibility, and SPSS software for data analysis.

Results

A total of 3765 urine samples were collected during the period July 2017 to June 2018, of which 346 (9.19%) were bacteriologically positive. Among isolated uropathogens, 97.9% were Gram-negative bacteria and 2.1% were Gram-positive bacteria (Staphylococcus aureus, Streptococcus and Enterococcus). A higher proportion of males than females were prone to UTIs in the ≤ 10 and > 60 years age groups, and a higher proportion of females than males were affected in all age groups between 10 and 60 years. Escherichia coli was the most predominant (83.8%) isolate, followed by Klebsiella spp. (5.8%). Most of the uropathogens were sensitive to cefotaxime in males. Approximately 49.3% of males and 41.6% of females were resistant to E. coli.

Conclusions

Cefotaxime is still considered to be effective against uropathogens but its use should only be reserved for complicated UTIs and should follow antibiotic guidelines in order to prevent the emergence of multidrug-resistant organisms.

Notes

Acknowledgements

The authors would like to gratefully acknowledge Ibn Sina Diagnostic Center, Badda, Dhaka, Bangladesh, for their whole-hearted support to this work.

Author Contributions

All authors contributed equally to this work.

Compliance with ethical standards

Conflict of interest

Md. Jahangir Alam, Runa Asma, Sumi Shohela Chowdury and Md. Rahimgir declare no conflicts of interest.

Funding

This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Biochemistry and MicrobiologyNorth South UniversityDhakaBangladesh
  2. 2.Department of MicrobiologyPrimeasia UniversityBananiBangladesh
  3. 3.Department of BiochemistryPrimeasia UniversityDhakaBangladesh
  4. 4.Department of MicrobiologyArmed Forces Medical CollegeDhaka Cantonment, DhakaBangladesh

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