Consider using selected antiepileptics to reduce the frequency of various types of headaches
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Antiepileptic drugs (AEDs) are among the best studied medications for the prevention of migraine and other headache disorders. The efficacy profiles of topiramate and valproate in headache prophylaxis are well established relative to those of other AEDs. Clinical data for other AEDs are generally limited, conflicting and/or show a lack of efficacy. Several factors, including the patient’s headache frequency and severity, tolerance of adverse events and the potential for pregnancy, should be considered when selecting an AED for headache prevention.
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Conflict of interest
The article was adapted from CNS Drugs 2018;32(8):735–46  by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.
The preparation of this review was not supported by any external funding.
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