Pre-exposure prophylaxis for HIV infection may be effective in older candidates, but proceed with caution
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The effectiveness and safety of tenofovir (TDF)-based therapy, which is the standard for pre-exposure prophylaxis (PrEP) for HIV infection, have not been specifically evaluated in older individuals. Major concerns relate to the older population being predisposed to kidney- and/or bone-related adverse events if they receive TDF-based PrEP. However, TDF-based PrEP may be a manageable treatment option in older candidates if careful screening, regular monitoring and appropriate sexual health education are also incorporated into the prevention plan.
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Conflict of interest
The article was adapted from Drugs & Aging 2018;35(6):485–91  by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.
The preparation of this review was not supported by any external funding.
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