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Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

  • Marie-Rose B. S. CrombagEmail author
  • Aurelia H. M. de Vries Schultink
  • Jacobine G. C. van Doremalen
  • Hans-Martin Otten
  • Andries M. Bergman
  • Jan H. M. Schellens
  • Jos H. Beijnen
  • Alwin D. R. Huitema
Original Research Article

Abstract

Background

Older patients with metastatic castration-resistant prostate cancer (mCRPC) may be more prone to chemotherapy-induced hematological toxicity, but tailored docetaxel dosing guidelines in older patients are lacking because of conflicting data.

Objective

This study aims to evaluate the impact of older age on the incidence of hematological toxicity in patients with mCRPC treated with docetaxel in daily clinical practice.

Methods

This study included patients with mCRPC treated with docetaxel between January 2006 and January 2016 at the Netherlands Cancer Institute and Medical Center Slotervaart for whom dosing and hematological toxicity data were available from electronic patient records. We evaluated the impact of age on the incidence of grade 3 and 4 hematological toxicity.

Results

In total, 175 patients treated with docetaxel were included in the analysis, with a median age of 67 years (range 47–86). Baseline hematological laboratory values were not age related. After the first treatment cycle, hematological toxicity occurred significantly more frequently in the oldest age quartile (25%, p = 0.02) than in the younger age quartiles (9%, 11%, and 7%, respectively, for age quartiles 1, 2, and 3).

Conclusion

The risk of hematological toxicity was significantly higher in the oldest age quartile than in younger patients with mCRPC treated with docetaxel in daily clinical practice.

Notes

Compliance with Ethical Standards

Funding

No sources of funding were used to assist in the conduct of this study or the preparation of this article.

Conflict of interest

JHB and JHMS are part-time employees and shareholders of Modra Pharmaceuticals and hold a patent on oral taxane pharmaceutical formulations. M-RBSC, AHMdVS, JGCvD, H-MO, AMB, and ADRH have no conflicts of interest that are directly relevant to the content of this article.

References

  1. 1.
    European Medicines Agency. TAXOTERE (docetaxel). 2015.  https://doi.org/10.2307/825086.
  2. 2.
    European Medicines Agency. Summary of Product Characteristics—Opdivo. 2017.Google Scholar
  3. 3.
    Ho MY, Mackey JR. Presentation and management of docetaxel-related adverse effects in patients with breast cancer. Cancer Manag Res. 2014;6:253–9.  https://doi.org/10.2147/CMAR.S40601.CrossRefGoogle Scholar
  4. 4.
    Tannock I, de Wit R, Berry W. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502–12.CrossRefGoogle Scholar
  5. 5.
    Food and Drug Administration. Official label—Taxotere, NDA 020449. 2015.Google Scholar
  6. 6.
    Xu H, Xu L, Page JH, Cannavale K, Sattayapiwat O, Rodriguez R, et al. Incidence of anemia in patients diagnosed with solid tumors receiving chemotherapy, 2010–2013. Clin Epidemiol. 2016;8:61–71.  https://doi.org/10.2147/CLEP.S89480.CrossRefGoogle Scholar
  7. 7.
    Bhatt V, Saleem A. Review: Drug-induced neutropenia—pathophysiology, clinical features, and management. Ann Clin Lab Sci. 2004;34:131–7.Google Scholar
  8. 8.
    Sweetman SC. Martindale: the complete drug reference. 38th ed. Pharmaceutical Press; 2014.Google Scholar
  9. 9.
    Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2009;41:67–76.  https://doi.org/10.1080/03602530902722679.CrossRefGoogle Scholar
  10. 10.
    Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother. 2004;2:274–302.CrossRefGoogle Scholar
  11. 11.
    Tan JJL, Eastment JGJ, Poudel A, Hubbard RE, Re H, Hubbard RE. Age-related changes in hepatic function: an update on implications for drug therapy. Drugs Aging. 2015;32:999–1009.  https://doi.org/10.1007/s40266-015-0318-1.CrossRefGoogle Scholar
  12. 12.
    Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5:345–51.  https://doi.org/10.1016/j.amjopharm.2007.12.002.CrossRefGoogle Scholar
  13. 13.
    Lipschitz DA, Udupa KB, Milton KY, Thompson CO. Effect of age on hematopoiesis in man. Blood. 1984;63:502–9.Google Scholar
  14. 14.
    Shigeta K, Kosaka T, Yazawa S, Yasumizu Y, Mizuno R, Nagata H, et al. Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer. Int J Clin Oncol. 2015;20:605–12.  https://doi.org/10.1007/s10147-014-0746-7.CrossRefGoogle Scholar
  15. 15.
    ten Tije AJ, Verweij J, Carducci MA, Graveland W, Rogers T, Pronk T, et al. Prospective evaluation of the pharmacokinetics and toxicity profile of docetaxel in the elderly. J Clin Oncol. 2005;23:1070–7.  https://doi.org/10.1200/JCO.2005.03.082.CrossRefGoogle Scholar
  16. 16.
    Gerritse FL, Meulenbeld HJ, Roodhart JML, Van Der Velden MT, Blaisse RJB, Smilde TJ, et al. Analysis of docetaxel therapy in elderly (≥ 70 years) castration resistant prostate cancer patients enrolled in the Netherlands Prostate Study. Eur J Cancer 2013;49:3176–83.  https://doi.org/10.1016/j.ejca.2013.06.008.
  17. 17.
    Beer TM, Berry W, Wersinger EM, Bland LB. Weekly docetaxel in elderly patients with prostate cancer: efficacy and toxicity in patients at least 70 years of age compared with patients younger than 70 years. Clin Prostate Cancer. 2003;2:167–72.CrossRefGoogle Scholar
  18. 18.
    Wong H-L, Lok SW, Wong S, Parente P, Rosenthal M. Docetaxel in very elderly men with metastatic castration-resistant prostate cancer. Prostate Int. 2015;3:42–6.  https://doi.org/10.1016/j.prnil.2015.03.003.CrossRefGoogle Scholar
  19. 19.
    Jones GR, Lim. E-M. The National Kidney Foundation guideline on estimation of the glomerular filtration rate. Clin Biochem Rev. 2003;24:95–8.Google Scholar
  20. 20.
    Institute N Cancer; Common terminology criteria for adverse events (CTCAE). Common terminology criteria for adverse events v4.0 (CTCAE). 2009.Google Scholar
  21. 21.
    Hryniuk WM, Goodyear M. The calculation of received dose intensity. J Clin Oncol. 1990;8:1935–7.  https://doi.org/10.1200/jco.1990.8.12.1935.CrossRefGoogle Scholar
  22. 22.
    Puisset F, Alexandre J, Treluyer J-M, Raoul V, Roché H, Goldwasser F, et al. Clinical pharmacodynamic factors in docetaxel toxicity. Br J Cancer. 2007;97:290–6.  https://doi.org/10.1038/sj.bjc.6603872.CrossRefGoogle Scholar
  23. 23.
    Horgan AM, Seruga B, Pond GR, Alibhai SM, Amir E, de Wit R, et al. Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial. J Geriatr Oncol. 2014;5:119–26.  https://doi.org/10.1016/j.jgo.2013.12.001.Tolerability.CrossRefGoogle Scholar
  24. 24.
    Franke RM, Carducci MA, Rudek MA, Baker SD, Sparreboom A. Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer. J Clin Oncol. 2010;28:4562–7.  https://doi.org/10.1200/jco.2010.30.7025.
  25. 25.
    Sweeney CJ, Chen Y-H, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 2015;373:737–46.  https://doi.org/10.1056/NEJMoa1503747.CrossRefGoogle Scholar
  26. 26.
    Vale CL, Burdett S, Rydzewska LHM, Albiges L, Clarke NW, Fisher D, et al. Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data. Lancet Oncol. 2016;17:243–56.  https://doi.org/10.1016/S1470-2045(15)00489-1.CrossRefGoogle Scholar
  27. 27.
    Aapro MS, Bohlius J, Cameron DA, Lago LD, Donnelly JP, Kearney N, et al. 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. Eur J Cancer. 2011;47:8–32.  https://doi.org/10.1016/j.ejca.2010.10.013.CrossRefGoogle Scholar
  28. 28.
    De Morrée ES, Vogelzang NJ, Petrylak DP, Budnik N, Wiechno PJ, Sternberg CN, et al. Association of survival benefit with docetaxel in prostate cancer and total number of cycles administered: a post hoc analysis of the Mainsail study. JAMA Oncol. 2017;3:68–75.  https://doi.org/10.1001/jamaoncol.2016.3000.CrossRefGoogle Scholar
  29. 29.
    Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, et al. Recommendations for the use of WBC growth factors: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2015;33:3199–212.  https://doi.org/10.1200/JCO.2015.62.3488.CrossRefGoogle Scholar
  30. 30.
    Patrikidou A, Uccello M, Tree A, Parker C, Attard G, Eeles R, et al. Upfront docetaxel in the post-STAMPEDE world: lessons from an early evaluation of non-trial usage in hormone-sensitive prostate cancer. Clin Oncol. 2017;29:e174–5.  https://doi.org/10.1016/j.clon.2017.06.006.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marie-Rose B. S. Crombag
    • 1
    • 2
    Email author
  • Aurelia H. M. de Vries Schultink
    • 1
    • 2
  • Jacobine G. C. van Doremalen
    • 1
    • 3
  • Hans-Martin Otten
    • 4
  • Andries M. Bergman
    • 5
  • Jan H. M. Schellens
    • 2
    • 3
  • Jos H. Beijnen
    • 1
    • 2
    • 3
  • Alwin D. R. Huitema
    • 1
    • 2
    • 6
  1. 1.Department of Pharmacy and PharmacologyAntoni van Leeuwenhoek, The Netherlands Cancer Institute and MC SlotervaartAmsterdamThe Netherlands
  2. 2.Division of PharmacologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  3. 3.Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical SciencesUtrecht UniversityUtrechtThe Netherlands
  4. 4.Division of Medical OncologyMC SlotervaartAmsterdamThe Netherlands
  5. 5.Division of Medical OncologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  6. 6.Department of Clinical Pharmacy, University Medical Center UtrechtUtrecht UniversityUtrechtThe Netherlands

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